Biocytogen Pharmaceuticals Beijing

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Biocytogen Pharmaceuticals Beijing

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  • A clinical-stage Biotech committed to becoming a global headstream of new antibody drugs with proprietary fully human antibody discovery RenMice™ platforms. Biocytogen has launched Project Integrum, the world’s first large-scale antibody discovery screening program adopting an evidence-based in vivo efficacy screening methodology to concurrently generate and screen antibodies against over 1,000 potential druggable targets, including BIC/FIC mAbs/BsAbs/BsAb-ADCs/TCRm Abs/GPCRs.

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  • Highlights:
    - Recent bsADC deals: YH012 (HER2 x TROP2) with Radiance, B7H3 x PTK7 with Ideaya
    - 10 fully human bsAbs at PCC/IND stage, e.g. CTLA-4 x OX40, OX40 x OX40
    - 200+ TAA targets for “plug & play”
    - 20+ Bispecific ADCs with improved anti-tumor efficacy in preclinical studies, featuring BCG033: PTK7 x TROP2, BCG022: HER3 x MET
    - Most advanced bsADCs are in phase I
    - Trispecific TAA-CD3-4-1BB TCEs with enhanced T cell function and reduced safety risk
    - 10+ TCRm antibodies targeting intracellular TAAs including WT-1, KRAS, P53, AFP, GP100 NY-ESO-1, etc.
    - 100+ Nanobody initiatives, including BBB-crossing assets for CNS therapies
    - 7 innovative discovery platforms to generate different formats: fully human antibody mAb, common light chain bsAbs and bsAb-ADCs, nanobodies, TCR mimics, GPCR-targeting mAbs, and fully human TCRs
    - Platform licensing with Merck, BeiGene, Janssen, etc.
    - 1,000+ antibody target hits: targeting oncology, inflammatory and autoimmune diseases, infectious diseases, and neurodegenerative disease applications

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  • In-licensing  / collaboration opportunities, Out-licensing / collaboration opportunities, Network development

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